abstract：BACKGROUND AND AIMS:Biosimilar approval, such as Inflectra™ (CT-P13) for treating ulcerative colitis (UC) and Crohn's disease (CD), has reduced direct drug costs. Though clinicians are comfortable with biosimilar use in treatment-naïve patients, there are concerns in some jurisdictions that there are insufficient data ...

journal_title：Digestive diseases and sciences

authors： Bernard EJ,Fedorak RN,Jairath V

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Marijuana may be used by some patients with gastroparesis (Gp) for its potential antiemetic, orexigenic, and pain-relieving effects. AIMS:The aim of this study was to describe the use of marijuana by patients for symptoms of Gp, assessing prevalence of use, patient characteristics, and patients' perceived b...

journal_title：Digestive diseases and sciences

authors： Parkman HP,Sharkey EP,Nguyen LA,Yates KP,Abell TL,Hasler WL,Snape W,Clarke J,Schey R,Koch KL,Kuo B,McCallum RW,Sarosiek I,Grover M,Farrugia G,Tonascia J,Pasricha PJ,Frank A. Hamilton for the NIH Gastroparesis Consortium

更新日期：2020-08-01 00:00:00

abstract：:In recent years, three-dimensional (3-D) printing technology has become a standard tool that is used in several medical applications such as education, surgical training simulation and planning, and doctor-patient communication. Although liver surgery is ideally complemented by the use of preoperative 3-D-printed mode...

journal_title：Digestive diseases and sciences

authors： Larghi Laureiro Z,Novelli S,Lai Q,Mennini G,D'andrea V,Gaudenzi P,Marinozzi F,Engelmann C,Mookarje R,Raptis D,Rossi M,Jalan R

更新日期：2020-08-01 00:00:00

abstract：:Celiac disease (CD) is an immune-mediated enteropathy triggered by dietary ingestion of gluten in genetically susceptible patients. CD is often diagnosed by a "case-finding" approach of symptomatic patients. In recent times, the diagnostic paradigm has shifted to investigate patients who may be asymptomatic, but are a...

journal_title：Digestive diseases and sciences

authors： Kumral D,Syed S

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:Combined heart-liver transplantation (CHLT) has resulted in acceptable survival rates compared to orthotopic liver transplantation (OLT) alone and orthotopic heart transplantation alone. Using the US transplant registry, we compared outcomes following sequential and combined HLT. METHODS:We conducted a re...

journal_title：Digestive diseases and sciences

authors： Yamaguchi Y,Burrier C,Roth C,Tumin D,Beal EW,Washburn K,Hayes D Jr,Tobias JD

更新日期：2020-08-01 00:00:00

abstract：:Suppurative gastritis is an uncommon lesion and often an occult cause of upper abdominal pain without florid signs of a septic focus. There are two main phenotypic forms: (1) localized, also referred to as gastric abscess; and (2) diffuse, in which the differential diagnosis includes a more diverse range of benign and...

journal_title：Digestive diseases and sciences

authors： Coles M,Madray V,Cox K,Uy P,Sharma A

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is an established causal factor for non-cardia gastric cancer. H. pylori negative gastric cancer prevalence among US patients is unclear. METHODS:This retrospective cohort study examined H. pylori prevalence among consecutive patients with incident non-cardia gastric adenocarci...

journal_title：Digestive diseases and sciences

authors： Nguyen TH,Mallepally N,Hammad T,Liu Y,Thrift AP,El-Serag HB,Tan MC

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study. METHODS:Altogether 1064 patients were...

journal_title：Digestive diseases and sciences

authors： Airaksinen L,Myllymäki L,Kaukinen K,Saavalainen P,Huhtala H,Lindfors K,Kurppa K

更新日期：2020-07-23 00:00:00

abstract：BACKGROUND:There is a large Barrett's esophagus patient population undergoing endoscopic surveillance. Methods to stratify patients into higher and lower risk groups may enable more varied surveillance intervals for patients with non-dysplastic Barrett's esophagus that could optimize use of endoscopy resources. OBJECT...

journal_title：Digestive diseases and sciences

authors： Kunzmann AT,Coleman HG,Johnston BT,Turkington RC,McManus D,Anderson LA,Thrift AP

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:Although the use of cold snare polypectomy (CSP) has spread rapidly, its safety for pedunculated (Ip) polyps remains controversial. In particular, the outcomes of hot snare polypectomy (HSP) and CSP for Ip polyps have not been previously compared. AIMS:This study evaluated whether the rate of delayed postpo...

journal_title：Digestive diseases and sciences

authors： Arimoto J,Chiba H,Ashikari K,Fukui R,Tachikawa J,Okada N,Suto T,Kawano N,Niikura T,Kuwabara H,Nakaoka M,Ida T,Goto T,Nakajima A

更新日期：2020-07-04 00:00:00

abstract：BACKGROUND:The age to stop screening or surveillance colonoscopy is not well established, and unplanned hospital use after colonoscopy in the elderly is not well understood. AIMS:To evaluate unplanned emergency department (ED) visits and hospitalization in patients over 75 within 7 days of outpatient colonoscopy. MET...

journal_title：Digestive diseases and sciences

authors： Grossberg LB,Papamichael K,Leffler DA,Sawhney MS,Feuerstein JD

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Determining the risk stratification of nonvariceal upper gastrointestinal bleeding (NVUGIB) plays a vital role in treating upper gastrointestinal bleeding (UGIB). Traditional scores like Glasgow-Blatchford score (GBS), Rockall score (RS), and AIMS65 score have been widely utilized in UGIB practice, however e...

journal_title：Digestive diseases and sciences

authors： Yue W,Liu Y,Jiang W,Huang J,Liu J

更新日期：2020-06-24 00:00:00

abstract：BACKGROUND AND AIMS:Percutaneous gastrostomy (PEG) is a common inpatient procedure. Prior data from National Inpatient Sample (NIS) in 2006 reported a mortality rate of 10.8% and recommended more careful selection of PEG candidates. This study assessed for improvement in the last 10 years in mortality rate and complica...

journal_title：Digestive diseases and sciences

authors： Stein DJ,Moore MB,Hoffman G,Feuerstein JD

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND AND AIM:Although the serum sodium level has been reported to be a prognostic and predictive marker for the therapeutic effects of lung cancer and renal cell carcinoma treated with molecular targeted therapy, the serum sodium level has not been investigated in hepatocellular carcinoma (HCC) patients treated w...

journal_title：Digestive diseases and sciences

authors： Kegasawa T,Sakamori R,Maesaka K,Yamada R,Tahata Y,Urabe A,Kodama T,Hikita H,Imanaka K,Ohkawa K,Hiramatsu N,Oshita M,Yamada Y,Inada M,Yakushijin T,Imai Y,Tatsumi T,Takehara T

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND AND AIMS:Current genetic research of nonalcoholic steatohepatitis (NASH) cirrhosis is limited by our ability to accurately identify cases on a large scale. Our objective was to develop and validate an electronic health record (EHR) algorithm to accurately identify cases of NASH cirrhosis in the EHR. METHODS...

journal_title：Digestive diseases and sciences

authors： Danford CJ,Lee JY,Strohbehn IA,Corey KE,Lai M

更新日期：2020-06-13 00:00:00

abstract：BACKGROUND:Peppermint oil is well known to inhibit smooth muscle contractions, and its topical administration during colonoscopy is reported to reduce colonic spasms. AIMS:We aimed to assess whether oral administration of IBGard™, a sustained-release peppermint oil formulation, before colonoscopy reduces spasms and im...

journal_title：Digestive diseases and sciences

authors： Han JY,Moosvi Z,Duh E,Park S,Albers GC,Samarasena JB,Karnes W

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:Diarrhea, a major pathological hallmark of inflammatory bowel disease, is characterized by a significant reduction in the expression and function of key intestinal ion transporters. The adoptive naïve CD4+ T cell transfer colitis is an immune-based, chronic colitis mouse model which resembles human Crohn's d...

journal_title：Digestive diseases and sciences

authors： Jayawardena D,Tyagi S,Nazmi A,Olivares-Villagómez D,Dudeja PK

更新日期：2020-06-01 00:00:00

abstract：:Gastroparesis is characterized by delayed gastric emptying, with symptoms such as nausea, vomiting and abdominal pain, in the absence of mechanical obstruction. In most cases, it is idiopathic although diabetes mellitus is another leading cause. The physiology of gastric emptying is a complex process which is influenc...

journal_title：Digestive diseases and sciences

authors： Sullivan A,Temperley L,Ruban A

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The present study aimed to identify the differential expressed genes that are related to acute pancreatitis. METHODS:Microarray datasets GSE109227 and GSE3644 were downloaded from the public database and analyzed to screen the genes. Afterward, integrated analysis of these genes were performed, inc...

journal_title：Digestive diseases and sciences

authors： Fan L,Hui X,Mao Y,Zhou J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Gastrointestinal motility disorder is an important pathological basis for functional dyspepsia (FD). Epigastric ache and discomfort are the main symptoms of FD, and ghrelin deficiency is closely related to the occurrence and development of FD. While electroacupuncture (EA) alleviated the symptoms of FD patie...

journal_title：Digestive diseases and sciences

authors： Tang L,Zeng Y,Li L,Wang J,Peng D,Zhang T,Zhang H,An X

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Interferon regulatory factor 9 (IRF9) acts as a negative regulator of sirtuin-1 (SIRT1) to participate in many diseases. However, the role of SIRT1 and IRF9 in hyperlipidemia acute pancreatitis associated with kidney injury is unclear. AIMS:To explore the function of SIRT1 and IRF9 in hyperlipidemia acute p...

journal_title：Digestive diseases and sciences

authors： Liu Y,Sun Y,Xue BH,Wang XD,Yu WL

更新日期：2020-05-28 00:00:00

abstract：INTRODUCTION:Increased nonacid reflux is diagnosed in a subgroup of patients with gastroesophageal reflux disease who often present with reflux symptoms refractory to proton-pump inhibitor therapy. Despite the prevalence of this condition, the management approach for patients with increased nonacid reflux can often be ...

journal_title：Digestive diseases and sciences

authors： Reddy CA,Watts L,Baker JR,Chen JW

更新日期：2020-05-23 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma is a devastating disease with a 2% 5-year survival if the disease has spread outside the liver. The enzyme aspartate beta-hydroxylase (ASPH) has been demonstrated to be highly expressed in cholangiocarcinoma but not in normal bile ducts and found to stimulate tumor cell migration. In addit...

journal_title：Digestive diseases and sciences

authors： Nagaoka K,Ogawa K,Ji C,Cao KY,Bai X,Mulla J,Cheng Z,Wands JR,Huang CK

更新日期：2020-05-22 00:00:00

abstract：INTRODUCTION:Crohn's disease (CD) and ulcerative colitis (UC) are associated with considerable direct healthcare costs. There have been few comprehensive analyses of all IBD- and non-IBD comorbidities that determine direct costs in this population. METHODS:We used data from a validated cohort of patients with inflamma...

journal_title：Digestive diseases and sciences

authors： Cai W,Cagan A,He Z,Ananthakrishnan AN

更新日期：2020-05-20 00:00:00

abstract：BACKGROUND:Sigmoid volvulus is a common condition in elderly patients with elongated colons. Although endoscopic de-torsion is effective as the primary treatment of sigmoid volvulus, elective surgery is recommended because of the high risk of recurrence and high mortality rate. AIM:The aim of this study was to determi...

journal_title：Digestive diseases and sciences

authors： Kusunoki R,Fujishiro H,Miyake T,Suemitsu S,Kataoka M,Fujiwara A,Tsukano K,Kotani S,Yamanouchi S,Aimi M,Tanaka M,Miyaoka Y,Kohge N,Imaoka T,Yuasa K,Kodama K,Ishihara S,Kinoshita Y

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:Endoscopic ablation of duodenal ampullary malignancy has not been fully assessed. AIMS:The study aimed to evaluate the efficacy and safety of Endoscopic retrograde cholangiopancreatograpy (ERCP)-guided radiofrequency ablation (RFA) for inoperable ampullary cancer. METHODS:Patients with inoperable ampullary...

journal_title：Digestive diseases and sciences

authors： Hu B,Sun B,Gao DJ,Wu J,Ye X,Xia MX,Wang TT

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Data on real-life patterns of biologic use for inflammatory bowel disease (IBD) are scarce. AIMS:We aimed to examine the patterns of biologic use and the factors associated with non-persistence and switching of biologics in Korean IBD patients. METHODS:Using National Health Insurance claims, we collected d...

journal_title：Digestive diseases and sciences

authors： Jung YS,Han M,Park S,Cheon JH

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Controlled attenuation parameter (CAP) has been developed to estimate the extent of hepatic steatosis. AIMS:The purpose was to evaluate the usefulness of CAP in assessing hepatic steatosis and its change using magnetic resonance imaging proton density fat fraction (MRI-PDFF) as reference standard. METHODS:...

journal_title：Digestive diseases and sciences

authors： Wang JH,Ou HY,Yen YH,Chen CH,Lu SN

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Notoginsenoside R1 (NG-R1) is the predominant active ingredient and a novel triterpene saponin compound extracted from the roots of Panax notoginseng. To date, to the best of our knowledge, there are no previous studies concerning the effect of NG-R1 on hepatocellular carcinoma (HCC). AIMS:To investigate th...

journal_title：Digestive diseases and sciences

authors： Li Y,Li Z,Jia Y,Ding B,Yu J

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Gastroparesis is a heterogeneous disorder. Patient characteristics and treatment responsiveness may differ based on the extent of delay in gastric emptying. AIMS:Characterize gastroparesis patients based on the degree of delay in gastric emptying, and assess the relationship of patient demographics, symptom...

journal_title：Digestive diseases and sciences

authors： Navas CM,Wadas ED,Zbib NH,Crowell MD,Lacy BE

更新日期：2020-04-18 00:00:00

abstract：BACKGROUND:Diagnosis of eosinophilic esophagitis (EoE) requires manual quantification of tissue eosinophils. Eosinophil peroxidase (EPX) is an eosinophil-specific, cytoplasmic granule protein released during degranulation. AIMS:The objective of this study was to evaluate image analysis of EPX immunohistochemistry as a...

journal_title：Digestive diseases and sciences

authors： Wright BL,Doyle AD,Shim KP,Pai RK,Barshow SM,Horsley-Silva JL,Luo H,Rank MA,Jacobsen EA,Katzka DA,Kita H,Dellon ES

更新日期：2020-04-04 00:00:00

abstract：BACKGROUND AND AIMS:Fatigue significantly impacts the quality of life of patients with inflammatory bowel disease (IBD). This study aimed to assess the effect of a personalized, intensive exercise program on fatigue, health-related quality of life (HRQoL), and cardiorespiratory fitness in patients with quiescent IBD an...

journal_title：Digestive diseases and sciences

authors： van Erp LW,Roosenboom B,Komdeur P,Dijkstra-Heida W,Wisse J,Horjus Talabur Horje CS,Liem CS,van Cingel REH,Wahab PJ,Groenen MJM

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Previous studies have shown vitamin D status to be associated with disease activity in patients with inflammatory bowel disease (IBD), but its influence on the clinical course of IBD has not been established. AIMS:We aimed to analyze whether the serum 25-hydroxyvitamin D3 [25(OH)D] status is associated with...

journal_title：Digestive diseases and sciences

authors： Ham NS,Hwang SW,Oh EH,Kim J,Lee HS,Park SH,Yang DH,Ye BD,Byeon JS,Myung SJ,Yang SK

更新日期：2020-03-26 00:00:00

abstract：BACKGROUND:Liver metastasis is an indicator of unfavorable responses to immunotherapy in colorectal cancer patients. However, the difference of immune microenvironment between primary tumors and liver metastases has not been well understood. PATIENTS AND METHODS:Fifty-four colon cancer with liver metastasis patients w...

journal_title：Digestive diseases and sciences

authors： Zhou SN,Pan WT,Pan MX,Luo QY,Zhang L,Lin JZ,Zhao YJ,Yan XL,Yuan LP,Zhang YX,Yang DJ,Qiu MZ

更新日期：2020-03-19 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease characterized with the spectrum of hepatic steatosis, inflammation, and fibrosis. The etiology of NAFLD remains incompletely understood. Numerous studies have implied that the gut microbiota (GM) is involved in the development of NAFLD, ...

journal_title：Digestive diseases and sciences

authors： Shama S,Liu W

更新日期：2020-03-01 00:00:00

abstract：:This manuscript is a secondary analysis of a large multicenter randomized controlled trial. The primary study is Cross RK et al., A Randomized Controlled Trial of TELEmedicine for patients with Inflammatory Bowel Disease (TELE-IBD). Am J Gastroenterol, 2019 Mar. ...

journal_title：Digestive diseases and sciences

authors： Bilgrami Z,Abutaleb A,Chudy-Onwugaje K,Langenberg P,Regueiro M,Schwartz DA,Tracy JK,Ghazi L,Patil SA,Quezada SM,Russman KM,Quinn CC,Jambaulikar G,Beaulieu DB,Horst S,Cross RK Jr

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Patients with irritable bowel syndrome (IBS) frequently have meal-related symptoms and can recognize specific trigger foods. Lactose intolerance is a well-established carbohydrate malabsorption syndrome that causes symptoms similar to IBS such as bloating, abdominal pain, and diarrhea. However, the prevalenc...

journal_title：Digestive diseases and sciences

authors： Kim SB,Calmet FH,Garrido J,Garcia-Buitrago MT,Moshiree B

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia is a hallmark of advanced liver disease. Platelets, growth factors (GFs), and vascular integrity are closely linked factors in disease pathogenesis, and their relationship, particularly in early disease stages, is not entirely understood. The aim was to compare circulating platelets, growth ...

journal_title：Digestive diseases and sciences

authors： Ali RO,Moon MS,Townsend EC,Hill K,Zhang GY,Bradshaw A,Guan H,Hamilton D,Kleiner DE,Auh S,Koh C,Heller T

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND/AIMS:The purpose of this study is to explore the inhibition or activation effects of microRNA-146 B on the expression of PTP1B in gastric cancer cells. METHODS:The expressions of PTP1B and miR-146b in gastric cancer were detected by RT-qPCR. The effects of miR-146b on cell apoptosis and proliferation of gas...

journal_title：Digestive diseases and sciences

authors： Xu J,Zhang Z,Chen Q,Yang L,Yin J

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients. METHODS:A total of 163 patients were randomized into two groups: Group A to consume...

journal_title：Digestive diseases and sciences

authors： Bahrudin MF,Abdul Rani R,Tamil AM,Mokhtar NM,Raja Ali RA

更新日期：2020-02-01 00:00:00